Relationship Between Renal Failure and Creatinine

Recently, I have received a letter from a American woman who was diagnosed with Renal Failure three days ago. Her doctor tells her that her creatinine is high. She does not understand the relationship between Renal Failure and creatinine. Therefore , I write this article to introduce the relationship between Renal Failure and creatinine.
High creatinine occurs after the kidneys have been invaded by various diseases. The damaged renal inherent cells have phenotype transformation with forming the pathological changes. It stimulates the kidney endothelial fiber cells and makes them changed into myofibroblast.
Then we talk about mechanism, the transformed myofibroblast cells will invade and stimulate the normal kidney tissue at the same time, having the same pathological changes and then expanding the whole kidneys, thus leading to Renal Failure. At this time, because the kidneys are constantly damaged, function of discharging waste will decrease, which result in the gathering of the creatinine and other toxin. Therefore, there is creatinine in blood and urea nitrogen increased the creatinine in urine decreased and the two kidneys’ filterability decreased and so on. In addition, patients also have symptoms of hypertension, highly dropsy and so on. The reason for the high creatinine still has relationship with four kidney damaging periods:
1. Compensatory Stage of Renal Failure
The GFR (glomerular filtration rate) is 50 ml to 80 ml/min. At the moment the endogeny also refers to the Ccr decreased, but when it is above 50 ml/min, Scr is below 178 μmol/l, Blood Urea Nitrogen is below 9 mmol/l, there is no clinical symptom. It is also called Renal Reserving Function Declined stage.
2. Discompensation Stage of Renal Failure
Ccr, 25—50 ml per minute; Scr increased to more than 178 μmol/l (2 mg/dl); blood urea nitrogen, over 9 mmol/l (25 mg/dl). There is no uncomfortable feeling except mild anemia, symptoms of digestion and the nocturnal enuresis increased. However, after tiring work, infection, fluctuation of blood pressure or having over much protein, the clinical symptoms will become serious. It is also called the Azotemia Stage.
3. Stage of Renal Failure
Ccr, 10—25 ml/min; Scr, 221—442 μmol/l; blood urea nitrogen, 17.9—21.4 mmol/l. Most of patients with Renal Failure suffer from symptoms of digesting tract and Anemia, and mild metabolic acidosis and calcium and phosphate metabolize abnormally without obvious disordering metabolism of salt and water. At this moment, kidneys still have certain function, so it is regarded as the early stage of Uremia.
4. Uremia stage
Scr is over 442 μmol/l and blood urea nitrogen is more than 21.4 mmol/l, various Uremia symptoms like obvious anemia, serious nausea, vomiting and all kinds of nervous system complication, even coma will occur. Besides, symptoms such as no salt and water metabolism and acid- base disturbance, little urine or no urine will happen to patients of Renal Failure. When the Ccr is less than 10 ml per minute and Scr is over 707 μmol/l, it is called terminal period, or the late period of Uremia.

In a word, the creatinine is various with the development of Renal Failure. Patients of Renal Failure should pay attention to the changes of their creatinine which can reflects their condition of the disease. If you still can not understand it, you can contact us by email, message or telephone.

If you have any questions about kidney disease , you can sent your cases , Our kidney expert will reply as soon as possible . I hope you'll get well soon !

The Confusion of a Patient with Renal Failure

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Here is a message from a patient with Renal Failure, in which she expressed the confusion about her medical conditions.
Hi doctor, my creatinine clearance was 17.26ml/mins, my 24 hour urinary protein was 342 and the machine value was 21.6, but I have no symptoms of a kidney failure person, like blood in urine, swelling of feet and shortness of breathe. I want to know why and I wonder where I stand.
From what she said, we can feel that she is very surprised about the severity of her disease and confused why she did not present some symptoms of Renal Failure. Actually, many patients have the similar experience that no obvious symptoms attract their attention, but it has been at the late stages of Renal Failure when it is diagnosed.
Renal compensation
The kidneys in the body boast a great compensation. Even if we lost one kidney, we still can feel normally. Only when more than half function of kidney fails emerge the obvious symptoms. The common urine test includes creatinine, protein and blood in urine. The patients usually never know about creatinine clearance test or GFR (glomeruli filtration rate). GFR is the best one reflecting the function of kidney and even more precise than the value of clearance creatinine test.
Late symptoms
Symptoms do not go hand in hand with pathological damages. They usually happen behind pathological damages. Even creatinine is dull to the damage of glomeruli. The normal values of test in proteinura or blood urine dose not mean that the kidneys are intact, because those tests can not give us the real degree of pathological damage. Although GFR is the most precise, most doctors tend to avoid efforts to get it. Traditionally, they just try to control the symptom at the beginning. Then they seem to wait for the creatinine exceeding 450 umol/L and make the patients receive dialysis, which just can remove creatinine and can not stop the more creatinine increasing. The point of 450 umol/L usually is a watershed, because at this time GFR is usually less than 30 ml/min. If the doctors take effective measures to control creatinine, it is possible to heighten GFR and stop the development of Renal Failure. However, the traditional treatments like hormone and immunosuppressant do not have this therapeutic effect.

If you have any questions about kidney disease , you can sent your cases , Our kidney expert will reply as soon as possible . I hope you'll get well soon !
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Can People Take Creatine Supplementation with High Blood Pressure?

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Creatine supplementation is popular among people who want to increase their muscle mass, especially, it is used for the athletes to increase their muscle strength. However, whether these supplementation is appropriate for people with high blood pressure?
In fact, creatine supplement may present danger to you if you suffer from high blood pressure.
In a study published in the "American Journal of Hypertension" examining the relations between serum creatinine levels and hypertension, the researchers have concluded that the increasing creatinine level may affect the hypertension.
According to related knowledge, creatinine can make your muscle retain the water, thus increasing the concentration of your urine. As times pass by, that may lead to the decline of renal function.
In the other hand, declined renal function leads to the excess fluids stay in your blood vessels, which further raise the blood pressure.
In related study researchers have found that the elevated serum creatinine level is more commonly seen in the aged individuals. This may be one of the explanations on why the elder people are at a higher risk for high blood pressure.
Surely, more studies are still needed to make certain the relations between the high serum creatinine level and hypertension as well as the kidney damage.
So if you are just suffering from high blood pressure, you should consult your doctor or our expert on line before you take any creatine supplementation. More attentions are necessary for protect your kidneys from any possible harms.

Do you have any question? You can leave a message , Or you Could describe your symptoms to our expert. Our expert will reply you as soon as possible. Please make sure you have left your contact information to us.
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Creatinine index

A creatinine edit this section
Creatinine is a product of muscle metabolism in the human body. Each 20g muscle metabolism can produce 1mg creatinine.
Creatinine is mainly excreted by glomerular filtration, serum creatinine from exogenous and endogenous two inside. Exogenous creatinine is meat product in the body metabolism. Endogenous Creatinine is a product of metabolism in muscle tissue in vivo. When meat intake is stable, the body's muscle metabolism has not changed, creatinine generation will be relatively constant.
2 creatinine index edit this section
Including serum creatinine, creatinine (Cr) and urine creatinine, serum creatinine (Cr) is an important indicator of renal function, serum creatinine increased mean renal damage. Mainly from the blood through urine creatinine glomerular filtration excreted in the urine creatinine. Pathological reduction Tip: acute and chronic renal failure and severe congestive heart failure, muscle atrophy and so on.
2.1 serum creatinine (Cr)
Is an important indicator of renal function, serum creatinine increased mean renal damage.
[Reference] men 53-106μ mOI / L, women 44-97μmol / L
[The clinical significance] pathologically elevated creatinine indicate ① reduce renal excretion, suggesting: renal failure, uremia, severe congestive heart failure; ② body creatinine generate excessive Tip: gigantism, acromegaly.
[Testing requirements] 12 hours of fasting venous blood.
2.2 urine creatinine
Mainly from the blood after glomerular filtration excreted in the urine creatinine.
[Reference] 8.4-1 3.25mmol / 24-hour urine
[The clinical significance] pathological reduce Tip: acute and chronic renal failure and severe congestive heart failure, muscle atrophy and so on.

[Testing requirements] urine specimens from 24 hours.

Tag: High Creatinine Level

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Creatinine 560 anemia how should I do?

Creatinine 560 anemia way? Anemia is an important symptom of chronic kidney disease, and with the degree of renal dysfunction were parallel. Confirmed clinical practice, with serum creatinine concentration, hemoglobin decreased, this time as taking blood transfusions, ineffective, and take general way to promote bone marrow cell proliferation, but also have no effect.
This is because in the initial stage of erythropoiesis, which is the primitive blood cells in the bone marrow to differentiate into red blood cells in the process of the original, there is a glycoprotein involved in essential, which is erythropoietin. There is no activity in plasma erythropoietin former, only in the kidneys under erythropoietic factor effects can become active erythropoietin. Kidneys secrete erythropoietin factor is next to the site of the ball glomerular cells.
Creatinine 560 anemia way? When glomerular lesions, will glomerular filtration dysfunction, serum creatinine increased, but also inevitably damage the next ball cells, reduce the secretion of erythropoietin factor affecting of red blood cells in bone marrow. Of course, blood creatinine, increased blood urea nitrogen, and the blood of some other toxic substances also inhibit bone marrow itself, but also affects the metabolism of iron and folic acid, and iron and folic acid is the raw material to generate hemoglobin. Clinical can also be observed, renal failure patients erythrocyte fragility, shortened life expectancy.

All these factors have contributed to chronic kidney disease patients are often difficult to correct anemia. With the improvement in renal function and reduce serum creatinine concentration, anemia symptoms will gradually reduce. For the treatment of hepatic tissue muscle, you need to have impaired renal intrinsic cells to repair, and be controlled inflammatory reaction is happening, simply taking Niaoduqing down muscle and other liver drug does not work, the outcome can only be more and kidney damage the more severe, only the frequency of dialysis treatment or dialysis faster and faster, and the exorbitant costs. We recommend that you accept Chinese medicine, the use of traditional Chinese medicine active substances intrinsic cells repair the kidney, while Western medicine adjuvant therapy, long-term adherence, expected recovery of renal function, effectively reducing muscle liver.

Creatinine 700 and often a fever about it, what is the reason triggered?

Creatinine 700 and often have a fever Always relations, in addition, resulting in elevated serum creatinine, there are many reasons, one, a lot of sweat during the summer or done strenuous exercise, the patient no method Hurry supply the body needed moisture, which results in elevated creatinine.
2, kidney disease cure after a rebound, there are probably causing a rapid increase in creatinine.
3, prolonged high blood pressure, diabetes, no method seize the time to get to control, but also showed a lot of proteinuria PRO, also resulting in elevated creatinine. Such patients exhibit more performance, be sure to go to a regular hospital for a detailed examination of kidney biochemistry and see the development of the disease.
Creatinine is an indicator of kidney soundness judgment, elevated serum creatinine stating that patients have impaired kidney glomerular filtration rate is reduced, resulting in the body's muscle metabolites no method discharged accumulation occurred, resulting in the rapid rise of creatinine high.
Side effects of high creatinine very large, the patient is important to note, otherwise it will lead to even more severe kidney disease, so patients should be sure to do it as soon as possible to check if you have any questions you can consult online Shijiazhuang kidney disease hospital doctor, we will give your professional answer.

How to reduce serum creatinine

Creatinine level is to test whether the human kidney health standards , high creatinine is physical abnormalities , high creatinine may be a symptom of kidney disease , if not lower creatinine values. It may cause kidney disease continues to deteriorate , eventually developed into uremia, endangering people's normal life. So how to reduce serum creatinine ? We still look at the introduction of experts it.
How to reduce serum creatinine for this problem ? Experts say the answer kidney patients , serum creatinine is generally considered endogenous serum creatinine, creatinine is a product of human muscle metabolism . In muscle , creatine primarily through irreversible non-enzymatic dehydration reaction slowly constitute creatinine, and then released into the blood , the urine excretion. Serum creatinine and thus the total body muscle closely , less susceptible to diet shadow .
Creatinine is a small molecule substances the body , usually through glomerular filtration , little absorption in the renal tubules , creatinine body produces daily , almost all excreted in urine , urine is generally not affected . How to reduce serum creatinine ? Continue to look down .
Clinical detection of creatinine in patients is one of the main ways to understand the common renal function . If serum creatinine is high , there is a likely increase in serum creatinine renal damage, kidney there is a problem , but there may simply be too high creatinine hyperthyroidism , acromegaly .
So when there is increase in serum creatinine , we must go to a regular hospital for the relevant inspection , in order to avoid misdiagnosis or delayed diagnosis . How to reduce serum creatinine ? Serum creatinine is generally common in pregnancy reduces muscle atrophy lesions and liver dysfunction. When physical examination or unintentionally discovered beyond the normal serum creatinine , we must pay attention, consult a doctor to be able to combine history and other laboratory tests to make an accurate analysis and diagnosis in order to identify the cause, early treatment.
How to reduce serum creatinine ? Western past the traditional treatment is only down creatinine , rather than to repair the basement membrane , as creatinine is not declining , even decline , this is temporary. Chinese medicine treatment can clear cause damage to the glomerular basement membrane immune complexes and diseased tissue while repairing damaged glomerular basement membrane . Just after repairing the damaged basement membrane , changing the structure of the kidney , expanding the area of ​​glomerular filtration , serum creatinine will gradually decline.

Above describes how you can lower serum creatinine should all know it ! I hope to be able to help you , your health is our responsibility , Beijing Chinese Medicine Hospital Guangji wholeheartedly for your service , if you do not understand what the problem or want to learn other aspects , can consult online experts .

How to reduce high creatinine

How to reduce creatinine high ? It is now understood by the patient , the Beijing Chinese Medicine Hospital Guangji said: creatinine high Description suffered kidney damage , high creatinine how to reduce it together Let us first understand the next creatinine is how ? ?
Shijiazhuang kidney hospital experts said: Because of the high creatinine in the kidneys by a variety of causes of violations , the first kidney damage inherent phenotypic transformation of cells , the formation of pathological changes , the final form of the kidney from the point to the surface from the local to the overall the expansion process of the spread of excitation of formula to enter the renal function of the arrangement, since the continuous renal damage , which features reduced excretion of waste , toxins such as creatinine and causing aggregation in the body , which appears in the partial blood creatinine high symptoms.
Shijiazhuang Kidney Disease Hospital, said: Today, more and more Chinese medicine treatment of patients with kidney disease, can effectively reduce creatinine .
[ Effective ] Shijiazhuang kidney hospital specialty treatments after decades of clinical research experts to 0 , to serve as the center of the patient , the treatment effect of gravity . From the condition of the individual patient to develop individualized treatment programs targeted to the pursuit of the best therapeutic effect as a starting point . Micro-Chinese Medicine nephropathy by kidney disease therapy .
 Micro-Chinese Medicine kidney disease therapy through the use of special herbs , so that patients in the healing process without surgery , no pain, treatment of kidney disease in a relatively comfortable environment .