Creatinine is a product of muscle metabolism in the human body. Each 20g muscle metabolism can produce 1mg creatinine.
Creatinine is mainly excreted by glomerular filtration, serum creatinine from exogenous and endogenous two inside. Exogenous creatinine is meat product in the body metabolism. Endogenous Creatinine is a product of metabolism in muscle tissue in vivo. When meat intake is stable, the body's muscle metabolism has not changed, creatinine generation will be relatively constant.
2 creatinine index edit this section
Including serum creatinine, creatinine (Cr) and urine creatinine, serum creatinine (Cr) is an important indicator of renal function, serum creatinine increased mean renal damage. Mainly from the blood through urine creatinine glomerular filtration excreted in the urine creatinine. Pathological reduction Tip: acute and chronic renal failure and severe congestive heart failure, muscle atrophy and so on.
2.1 serum creatinine (Cr)
Is an important indicator of renal function, serum creatinine increased mean renal damage.
[Reference] men 53-106μ mOI / L, women 44-97μmol / L
[The clinical significance] pathologically elevated creatinine indicate ① reduce renal excretion, suggesting: renal failure, uremia, severe congestive heart failure; ② body creatinine generate excessive Tip: gigantism, acromegaly.
[Testing requirements] 12 hours of fasting venous blood.
2.2 urine creatinine
Mainly from the blood after glomerular filtration excreted in the urine creatinine.
[Reference] 8.4-1 3.25mmol / 24-hour urine
[The clinical significance] pathological reduce Tip: acute and chronic renal failure and severe congestive heart failure, muscle atrophy and so on.
[Testing requirements] urine specimens from 24 hours.
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