Relationship Between Renal Failure and Creatinine

Recently, I have received a letter from a American woman who was diagnosed with Renal Failure three days ago. Her doctor tells her that her creatinine is high. She does not understand the relationship between Renal Failure and creatinine. Therefore , I write this article to introduce the relationship between Renal Failure and creatinine.
High creatinine occurs after the kidneys have been invaded by various diseases. The damaged renal inherent cells have phenotype transformation with forming the pathological changes. It stimulates the kidney endothelial fiber cells and makes them changed into myofibroblast.
Then we talk about mechanism, the transformed myofibroblast cells will invade and stimulate the normal kidney tissue at the same time, having the same pathological changes and then expanding the whole kidneys, thus leading to Renal Failure. At this time, because the kidneys are constantly damaged, function of discharging waste will decrease, which result in the gathering of the creatinine and other toxin. Therefore, there is creatinine in blood and urea nitrogen increased the creatinine in urine decreased and the two kidneys’ filterability decreased and so on. In addition, patients also have symptoms of hypertension, highly dropsy and so on. The reason for the high creatinine still has relationship with four kidney damaging periods:
1. Compensatory Stage of Renal Failure
The GFR (glomerular filtration rate) is 50 ml to 80 ml/min. At the moment the endogeny also refers to the Ccr decreased, but when it is above 50 ml/min, Scr is below 178 μmol/l, Blood Urea Nitrogen is below 9 mmol/l, there is no clinical symptom. It is also called Renal Reserving Function Declined stage.
2. Discompensation Stage of Renal Failure
Ccr, 25—50 ml per minute; Scr increased to more than 178 μmol/l (2 mg/dl); blood urea nitrogen, over 9 mmol/l (25 mg/dl). There is no uncomfortable feeling except mild anemia, symptoms of digestion and the nocturnal enuresis increased. However, after tiring work, infection, fluctuation of blood pressure or having over much protein, the clinical symptoms will become serious. It is also called the Azotemia Stage.
3. Stage of Renal Failure
Ccr, 10—25 ml/min; Scr, 221—442 μmol/l; blood urea nitrogen, 17.9—21.4 mmol/l. Most of patients with Renal Failure suffer from symptoms of digesting tract and Anemia, and mild metabolic acidosis and calcium and phosphate metabolize abnormally without obvious disordering metabolism of salt and water. At this moment, kidneys still have certain function, so it is regarded as the early stage of Uremia.
4. Uremia stage
Scr is over 442 μmol/l and blood urea nitrogen is more than 21.4 mmol/l, various Uremia symptoms like obvious anemia, serious nausea, vomiting and all kinds of nervous system complication, even coma will occur. Besides, symptoms such as no salt and water metabolism and acid- base disturbance, little urine or no urine will happen to patients of Renal Failure. When the Ccr is less than 10 ml per minute and Scr is over 707 μmol/l, it is called terminal period, or the late period of Uremia.

In a word, the creatinine is various with the development of Renal Failure. Patients of Renal Failure should pay attention to the changes of their creatinine which can reflects their condition of the disease. If you still can not understand it, you can contact us by email, message or telephone.

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