Cause of hepatitis B virus associated glomerulonephritis

Cause of hepatitis B virus associated glomerulonephritis what, this is the problem the majority of patients with hepatitis B associated glomerulonephritis friends who are very concerned about, once suffering from hepatitis B, a variety of disease complications after another came to the door. HBV nephritis is one complication. Hepatitis B virus can directly into the liver, the liver is severely damaged.
1, hepatitis B virus antigen - antibody immune complex deposition resulting in damage to the glomeruli: in this way can be pathogenic in two forms: (1) circulating immune complexes: mainly hepatitis B virus infection in humans, and their serum antibody in the blood circulation the formation of immune complexes deposition in the glomerular capillary loops, resulting in activation of the complement immune injury and disease. (2) in situ immune complex: mainly low molecular weight HBV e antigen through the first base film and subcutaneously implanted on glomerular hepatitis B virus e antibody bound immune complexes are formed in situ, deposition in glomeruli on the skin disease.
2, direct infection of kidney cells: Researchers found HBVDNA in hepatitis B virus associated glomerulonephritis patients with renal tissue, demonstrating the hepatitis B virus may directly infect the kidneys.

3, hepatitis B virus infection leads autoantibodies and cellular immune damage: damage and immune function autoimmune deficiencies have a great relationship, hepatitis B virus infection can stimulate the body to produce a variety of autoantibodies such as: Can DNA antibodies, anti-cytoskeleton component antibodies; hepatitis B virus infection of target cells can cause damage cytotoxic T cells to target cellular immunity, caused by the body's own immune response.
Shijiazhuang Kidney Disease Hospital

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