To emphasis cause of diabetic nephropathy
Everyday life, people with diabetes are no longer a minority, in the past
this disease is more common in the elderly, but in recent years, many young
people suffering from the disease. Did you know? After suffering from diabetes,
with the development of the disease, but also cause serious damage to the
kidneys, which is a common clinical diabetic nephropathy, let's take a look,
leading to what is the cause of the disease.
Of causes of diabetic nephropathy:
1, the genetic factors. This factor is the most major factors are responsible
for diabetic nephropathy, many of the patients are suffering from this disease
because of this factor in our lives there are a lot of good glycemic control may
also occur in patients with diabetic nephropathy. Glucose transporter protein is
the major glucose transporter in mesangial cells. And the occurrence of diabetic
nephropathy also showed family aggregation.
2, high blood pressure. For this reason there is no significant relationship
with the cause of diabetic nephropathy, but the time course of the disease to
hypertension or microalbuminuria period after blood pressure can accelerate the
deterioration of the progress of diabetic nephropathy and renal function,
increased urinary excretion of albumin in some family history of hypertension in
diabetic patients, the incidence of diabetic nephropathy was significantly
higher than in patients with no family history of hypertension.
3, hyperglycemia. This factor and lead to a great relationship with diabetic
nephropathy, diabetic nephropathy and high blood sugar closely related to poor
glycemic control can accelerate the development of diabetic nephropathy, a good
blood glucose control can significantly slow down its development. After the
high blood sugar and glycation endproducts cause increased mesangial cell
proliferation, extracellular matrix increased mesangial expansion, glomerular
basement membrane thickening.
4, renal hemodynamic abnormalities. In diabetic nephropathy, and played a key
role, and may even be the initial factor.
(1) high blood sugar, high glomerular perfusion, high filtration state,
increased pressure across the capillary wall, the expansion of mesangial cells,
epithelial cell foot process fusion and produce dense droplets, glomerular
epithelial cells from the basal membrane shedding.
(2) the glomerular basement membrane collagen Ⅳ messenger sugar nucleic acid
increased, the basement membrane thickening, and ultimately the formation of
diffuse mesangial nodular lesions occur glomerulosclerosis.
(3) In the case of increased pressure, increased protein filtration, also
deposited in the mesangial area and glomerular basement membrane, promoting
stromal proliferation, creating a vicious cycle, and can cause nodular and
diffuse glomerulosclerosis .
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