How melamine-induced renal failure

Kidney stones and kidney failure in 2008 has happened "milk" incident, several provinces in the country due to consumption of infant milk powder melamine was added after emergence. But their clinical toxicity mechanism of how, but it has been unclear. Recently, Shijiazhuang Kidney Disease Hospital study found that melamine-induced renal failure in infants with intestinal bacterial metabolism are closely
According to reports, some intestinal bacteria, especially bacteria of the genus Klebsiella, the nitrogen-containing compound having a metabolic (also called nitrogen fixation) The ability to metabolism in the intestinal tract of melamine, cyanuric acid and converted to its gradual degradation. Melamine and cyanuric acid is very low toxicity, but easily combined with each other to form crystals, these two substances into the blood circulation in the renal tubules with uric acid to form macromolecular complexes like stones, blocking tubules, resulting in kidney toxicity. Accordingly, the medical center research group proposed conversion of the intestinal bacterial metabolism and toxicity of melamine correlation hypothesis and confirmed animal testing.

The researchers pointed out that people in their daily lives on diet, metabolism, and biological effects of drugs there are significant individual differences, and these individual differences may result from differences largely intestinal microflora. Related study found that less than one percent of infants and young children in the consumption of milk containing melamine melamine-induced renal toxicity appear and urinary system diseases, suggesting that part of the reason for the occurrence of toxicity in infants, because they contain a high abundance of gut melamine bacteria capable of metabolizing degree Klebsiella bacteria such as sake; while only about 1% of the baby's body has Klebsiella, and after taking infant formula proportion of infants suffering from kidney toxicity fit just right.