Chronic renal allograft dysfunction is most prelude graft dysfunction , although new immunosuppressive agents and infection control measures applied , making the loss of acute graft decreased significantly , but the loss did not improve long-term kidney transplant , kidney transplant patients currently face the main risk factors for : cardiovascular disease , cancer, infection leads to death and chronic allograft dysfunction leading to graft loss.
Chronic renal allograft dysfunction caused by many factors , common are the following:
1 , donor type ( live or dead body ) ,
2 , hot and cold ischemic time is too long
3 , there have been previous acute rejection ,
4 , advanced chronic rejection
5 , primary glomerular disease recurrence ,
6 , delayed graft function after recovery
7, BK virus-associated nephropathy
8, the transplanted kidney Doppler ultrasound , vascular resistance index (RI)> 0.80
9 , diabetes, hypertension,
10 histocompatibility antigen pair does not meet the elevated levels of reactive antibody
11 , subclinical rejection,
12 , poor patient compliance , treatment does not conform
13 transplant renal artery stenosis
14 renal transplant urinary tract obstruction
15 recipients of lower urinary tract obstruction
16 , nephrotoxic immunosuppressive
The above situation can cause chronic renal allograft dysfunction , so the above reasons for the identification of renal transplant protection is very important. Many reasons clearly need a transplant biopsy , so transplant biopsy is very important. Only by examining and even transplant biopsy to confirm the diagnosis and for treatment in order to achieve therapeutic effect, prolonging graft survival time.
没有评论:
发表评论