What is the cause of the pathogenesis of diabetic nephropathy is?

What is the cause of diabetic nephropathy? Insulin diabetic nephropathy is caused by different etiology and pathogenesis absolute and relative lack of protein and fat that sugar metabolism, and chronic high blood sugar as the main clinical manifestations of systemic disease. So what is the cause of diabetic nephropathy is it?
What is the cause of diabetic nephropathy? Once kidney damage occurs diabetic patients with persistent proteinuria is irreversible disease often develop end-stage renal failure, diabetic nephropathy has become the leading cause of death in diabetic patients.
Etiology of diabetic nephropathy:
Hyperglycemia: diabetic nephropathy and high blood sugar closely related to poor glycemic control can accelerate the development of diabetic nephropathy, good blood glucose control can significantly retard its development. After hyperglycemia and advanced glycation end product formation caused increased mesangial cell proliferation, extracellular matrix increased mesangial expansion, glomerular basement membrane thickening.
Renal hemodynamic abnormalities in diabetic nephropathy, and played a key role, and may even be the initial factor.
1, high blood sugar, high glomerular perfusion, high filtration state, increased pressure across the capillary wall, the expansion of mesangial cells, epithelial cell foot process fusion and produce dense droplets, glomerular epithelial cells from the basement membrane the fall.
2, the glomerular basement membrane collagen Ⅳ messenger nucleic acid sugar increased, so that basement membrane thickening, and ultimately the formation of diffuse mesangial nodular lesions occur glomerulosclerosis.
3, in the case of increased pressure, increased protein filtration, also deposited in the mesangial area and glomerular basement membrane and promote matrix proliferation, creating a vicious cycle, and can cause nodular and diffuse glomerulosclerosis.
Hypertension and diabetic nephropathy is not directly related, but the original course of the disease to hypertension or microalbuminuria of the blood pressure can accelerate the deterioration of the progress of diabetic nephropathy and renal function, increased urinary excretion of albumin.
Genetic factors do not occur in most patients with kidney disease eventually, some long-term good glycemic control in patients with diabetic nephropathy can occur in the same glucose transporter protein -. ¹ (GLUÞ ¹) is the major glucose transporter in mesangial cells.
Recent studies have found that, among individuals with diabetes GLUÞ ¹ mesangial cells and differential regulation of menus on one factor may be susceptible to kidney damage in some patients. And the occurrence of diabetic nephropathy also showed family aggregation. Some have a family history of hypertension in diabetic patients. The incidence of diabetic nephropathy was significantly higher than that of patients with no family history of hypertension. In addition, between different ethnic incidence of diabetic nephropathy there are also differences. That this show that the incidence of diabetic nephropathy and genetic factors.

Conclusion is that the cause of diabetic nephropathy. Diabetic nephropathy is more common in patients with diabetes duration of more than 10 years, proteinuria is the earliest manifestations of diabetic nephropathy, the disease mechanism is very complex and not yet fully understood. Research data show that the pathogenesis of diabetic nephropathy is multifactorial.