Generally speaking, Chronic Kidney Failure develops slowly, but the delay of treatment may finally lead to Uremia. And the pathogenesis of Chronic Kidney Failure is as following:
1. Various of pathological damages to kidney will lead to blood microcirculation obstacles which cause ischemia and anoxia of renal tissue. Damages to renal blood endothelial cells will lead to the infiltration of inflammatory cells and the release of inflammatory mediators. Through this
2. The damaged renal histocyte will release a series of virulent cell factor and growth factor which promote the transform of the healthy renal cells. These transformed cells will continue to release toxic substances, thus aggravating the damage on kidneys.
3. After transformed, the cells, especially the renal fibroblast will secrete extracellular matrix which is difficult to be degraded. When large amounts of extracellular matrix pile up in kidneys, they will replace healthy renal unites, thus leading to glomerulosclerosis, kidney tubules & mesenchyme fibrosis and renal vessels fibrosis.
4. With the development of renal fibrosis, functional renal unites reduces gradually and renal function loses continuously, thus leading to the scar, and finally, the disease will develop into Renal Failure or even Uremia.
Chronic Kidney Failure happens gradually and it usually over years. The initial symptoms are usually very mild and could go unnoticed for years. Symptoms usually are noticed when it is too late and little can be done to reverse the situation.
Chronic kidney disease (CKD) slowly gets worse over time. In the early stages, there may be no symptoms. The loss of function usually takes months or years to occur. It may be so slow that symptoms do not occur until kidney function is less than one-tenth of normal.
The final stage of Chronic Kidney Failure is called end-stage renal disease (ESRD). The kidneys no longer function and the patient needs the effective treatments.
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