1, Ⅲ type of allergy: HSP patients with elevated serum IgA concentration in peripheral blood cells increased production of IgA in disease activity can be measured to contain IgA, C3, factor P and other circulating immune complexes; immunofluorescence can be measured IgA deposition in the skin capillaries and kidney capillaries and C3 consisting of immune complexes. It suggests allergens into the body to stimulate the body to produce antibodies to form circulating antigen - antibody complexes, which activate the complement system via the alternative pathway, causing damage to the small blood vessels.
2, Ⅰ type hypersensitivity: allergens into the body and the body become antigen binding protein, which stimulates the production of IgE antibodies that bind to blood vessels and connective tissue surrounding the mast cells and basophils in the blood cell surface material . When allergens enter again, directly bind IgE, stimulate mast cells released into the group, slow-reacting substance A and other inflammatory mediators, causing vasculitis. Making use of the two possible outcomes are caused by skin and visceral vasculitis, plasma extravasation, and ultimately lead to subcutaneous tissue, mucous membranes and internal organs bleeding and edema. Skin, joints, gastrointestinal tract, kidneys and other organs of vascular involvement, can cause a corresponding series of clinical symptoms.
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Shijiazhuang Kidney Disease Hospital
Shijiazhuang Kidney Disease Hospital is located in Shijiazhuang city, capital of Hebei Province, which is adjacent to the capital of China, Beijing. It was founded in 1986 and his name has become more widely known in recent decades.....Read More
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