Nephrotic syndrome is the most common primary glomerular disease, nephrotic syndrome and occult is its most common clinical manifestations. Now that the nephrotic syndrome, including form occult nephritis with nephrotic syndrome , not all benign lesions. Since the age of onset nephrotic syndrome in 20 to 30 years old, many patients progress to ESRD age than other kidney disease early. The disease caused by the economic burden on society and family has become a social problem worldwide . Therefore, may occur early diagnosis, early intervention treatment of nephrotic syndrome progression will undoubtedly be an important issue facing academia kidney disease . However, nephrotic syndrome vary greatly, it is possible that the clinical and pathological syndrome also includes several kinds of diseases , according to its development trends can be divided into three categories in the clinical, pathological and prognostic aspects: ( 1 ) patients showed occult process or stable condition , is not progress . Some scholars have proposed clinical manifestations of mild (Scr
Shijiazhuang kidney disease research institute to help you restore kidney health. http://www.kidneyservicechina.com
2014年1月18日星期六
Hematuria , mild proteinuria nephrotic syndrome with focal necrosis
Constitute their respective clinical and pathological characteristics of
patients with nephrotic syndrome, etiology , found involved in diseases
including : ANCA -positive primary vasculitis , nephrotic syndrome, systemic
lupus erythematosus, purpura, anti-glomerular basement membrane antibody
-associated nephropathy and no clear cause of idiopathic FSNGN. Therefore,
although the clinical cases of mild, but extremely active pathological dramatic
progress is possible and should be strengthened immunosuppressive therapy , may
be intravenous methylprednisolone pulse therapy treatment, and prednisone plus
cyclophosphamide therapy. Nephrotic syndrome is the name of an immune pathology
, renal pathology manifestation, is also one of FSNGN pathology . Recalling the
past 30 years, cases of nephrotic syndrome in the hospital they have accounted
for 10.3 percent FSNGN appear , indicating not uncommon. But our statistics
showed that the performance of FSNGN nephrotic syndrome while only 2.26% of all
nephrotic syndrome , it is possible to select the relevant cases with biopsy .
Performance FSNGN nephrotic syndrome clinically mainly involving young , no
significant multi-system involvement, and the occurrence of hematuria,
proteinuria was l00%, which with other pathological types of nephrotic syndrome
are not very different . DAmico , also reported that , compared with non-
necrotic nephrotic syndrome , FSNGN nephrotic syndrome in patients with similar
clinical manifestations , but its onset is more abrupt , and enter ESRD More ;
in pathology , its capillary extracellular hyperplasia and interstitial
mononuclear cells, T lymphocytes accumulate even more significant, it may be
related to the pathogenesis . Past performance is less of nephrotic syndrome
research FsNGN , but recently its importance as a vasculitis activity index and
prognosis of increasing attention. The study found. Appears FSNGN appearance and
crescents (especially cell crescent ) is consistent, which is considered a form
of kidney damage . Montinaro , also believes necrosis can cause rapid
progression of kidney damage and that may continue to stimulate IgA immune
complexes related. In fact, many studies have found that if there nephrotic
syndrome and focal necrosis ( or ) crescent formation , timely application of
intensive immunosuppressive therapy , the prognosis of patients with long-term
stability of renal function especially useful . Thus focal segmental necrotizing
lesions Chinese Journal of Nephrology Kidney disease activity has been prompted
. Guidance to strengthen an important indicator of immunosuppressive
therapy.
Nephrotic syndrome is the most common primary glomerular disease, nephrotic syndrome and occult is its most common clinical manifestations. Now that the nephrotic syndrome, including form occult nephritis with nephrotic syndrome , not all benign lesions. Since the age of onset nephrotic syndrome in 20 to 30 years old, many patients progress to ESRD age than other kidney disease early. The disease caused by the economic burden on society and family has become a social problem worldwide . Therefore, may occur early diagnosis, early intervention treatment of nephrotic syndrome progression will undoubtedly be an important issue facing academia kidney disease . However, nephrotic syndrome vary greatly, it is possible that the clinical and pathological syndrome also includes several kinds of diseases , according to its development trends can be divided into three categories in the clinical, pathological and prognostic aspects: ( 1 ) patients showed occult process or stable condition , is not progress . Some scholars have proposed clinical manifestations of mild (Scr
Nephrotic syndrome is the most common primary glomerular disease, nephrotic syndrome and occult is its most common clinical manifestations. Now that the nephrotic syndrome, including form occult nephritis with nephrotic syndrome , not all benign lesions. Since the age of onset nephrotic syndrome in 20 to 30 years old, many patients progress to ESRD age than other kidney disease early. The disease caused by the economic burden on society and family has become a social problem worldwide . Therefore, may occur early diagnosis, early intervention treatment of nephrotic syndrome progression will undoubtedly be an important issue facing academia kidney disease . However, nephrotic syndrome vary greatly, it is possible that the clinical and pathological syndrome also includes several kinds of diseases , according to its development trends can be divided into three categories in the clinical, pathological and prognostic aspects: ( 1 ) patients showed occult process or stable condition , is not progress . Some scholars have proposed clinical manifestations of mild (Scr
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