What caused by glomerular nephritis?

Glomerulonephritis is the cause.Idiopathic membranous nephropathy accounts for about 50% of nephrotic syndrome in adults.This section mainly introduces the idiopathic membranous glomerulonephritis, except on the diagnosis to, with the other all sorts of reasons of membranous nephropathy: (1) drugs: penicillamine, gold, captopril, etc.(2) the connective tissue diseases, such as sjogren's syndrome, systemic lupus erythematosus (sle).(3) mixed connective tissue disease, etc.(4) infection antigen and some parasites, such as malaria, schistosomiasis, etc.(5) hepatitis virus, hepatitis b caused by hepatitis b associated glomerulonephritis (HBV - ASGN), hepatitis c virus membranous nephropathy.6: malignant solid tumors in membranous nephropathy patients older than 60 years, about 22% of malignant tumors of the owner, and cancerous correlation nephritis, the most common for membranous nephropathy (60% ~ 60%.Common tumor such as lung, breast, gastrointestinal tract, ovarian, renal cell carcinoma, lymphoma, leukemia and class sarcoma and so on.7 other accompanying can have: diabetes, sarcoidosis, thyroiditis, myasthenia gravis, sickle red blood cell anemia, idiopathic thrombocytopenic purpura, multiple nodular polyarteritis, gangrenous pyoderma and bullous pemphigus, etc.
Nephritis whether genetic nephritis can genetic depends on what kind of nephritis.Some nephritis is hereditary, especially the hereditary nephritis, it can be inherited by parents to their children, is an autosomal dominant genetic disease, to pass on to future generations.
Etiology is not clear in the medical community about nephritis, generally considered synthetic genetic defects that cause may be the glomerular basement membrane.The disease has a characteristic, is obvious family history, often in a few generations of the family members, there are many blood in the urine, blood in the urine is the most common hereditary nephritis, with young men.
Nephritis have disease symptoms usually not obvious, when children often only urine check had mild proteinuria and hematuria, and often after an intense workout or upper respiratory tract infection after aggravating.General proteinuria with age, and gradually increase, the individual cases may have severe proteinuria.Rare increased blood pressure, often to the late only moderately elevated blood pressure.Disease continued to progress slowly, more male how serious illness, often died of chronic renal failure in the prime of life, female the illness is lighter, can have a normal life.
Glomerulonephritis for the long-term, slow deposition of immune complex in epithelial cells (also known as chronic immune complex deposition disease).Generally does not cause inflammation cell reaction, and through the terminal complement C3b ~ C9 is the membrane of attack of the complement system, cause basement membrane damage.Immunofluorescence showed granular IgG, C3 deposition in the glomerular basement membrane.Dixon in animal experiments, such as by 2 mg daily low dose of the opposite sex protein into the rabbit produce chronic disease, serum circulating immune complex deposition in membranous nephropathy.
This lateral basement membrane of epithelial immune complex formed in situ, and antigen can be "embedded" in advance, but also dirty layer epithelial cell surface glycoprotein with corresponding antibody immune complex formed in the surface of epithelial cells, and peels on the basement membrane.
Cell-mediated immune dysfunction is one of the immunological characteristics of this disease.Have information clew: especially in nephrotic syndrome episodes, T lymphocyte subgroup abnormalities, such as CD4, CD8 cell percentage and absolute value of abnormal, the former is on the high side, the latter.

Idiopathic membranous nephropathy associated with immune genetic marking the obvious;Such as European countries such as Britain, Germany, Spain and Finland are primary membranous nephropathy patients HLA - DR3 detection rate increased significantly, the primary membranous nephropathy patients showed that B cell antigen MT2, HLA - DR2 of Japanese primary membranous nephropathy patients was significantly higher, the United States, Britain, the disease patients B18 BfF1 - DR3 monotype was often worse prognosis than other types.