Reduced glomerular filtration rate causes

Really play the role of the kidney function is the function of each kidney cells . The main role is to clear the blood of harmful substances out of the body , this role is clear glomerular filtration rate . For this reason , people attach great importance to the strength of this glomerular filtration capabilities.
So, the glomerular filtration rate is how drop it? To understand this problem, we first analyze the glomerular filtration rate is how to achieve. The study found that glomerular filtration is achieved by two functions , one is a mechanical barrier function of the glomerulus , the second is the charge of glomerular barrier function . Mechanical barrier function means that there is a way to let the glomerular filtration of small molecules , macromolecules without allowing the ability to filter out . This ability to make blood macromolecules remain in the blood, while the extremely small molecules into the urine . And because the blood of toxins are generally small molecules , so the toxins generally be discharged into the urine. The so-called charge barrier means so there is a glomerular ability by positively charged species in order to ensure the negatively charged substances left in the blood. Through the above two functions is realized ensure glomerular filtration process for small molecules in the blood into the urine with the positive charge of the function, and when the urine flows through the tubules, and through its tubular back absorptive capacity , the urine of some ingredients beneficial to human body re- absorbed back into the blood and urine harmful part of the body.
Later, with the further discovery of medical science , people and uncover the secret of the glomerular filtration rate and renal tubular absorption function . Found in the glomerular layer of the mechanical barrier function is the function of glomerular capillary endothelial cells derived from the - capillary cell interaction mesangial cells and endothelial capillaries and played a mechanical barrier . Glomerular function is derived from the charge barrier layer of the glomerular function of skin cells - a capillary epithelial cells have the ability to control the negatively charged species through . Combined effect of these three functions in the cell before the glomerular filtration process to ensure that the small molecule with a positive charge in the blood is filtered into the urine. After the urine into the renal tubules , but also a function of the endothelial cells in the renal tubules - tubular epithelial cells in urine turn with a positive charge and the human and material needed for re- absorption. The four functions of cells through multiple checks ensures that the useful substances in the blood retained in the blood, into the urine and the harmful substances are eventually excreted .

But once the body against disease occurs , it will first cause changes in human blood components. And cause glomerular and tubular load exceeds the capacity of their work , and the emergence of injury or damage to the original filtration balance. The nature of this damage is to break the above four functions of cells or one or two or all destroyed. For this study found a decrease in the glomerular filtration rate is often said , in essence, is the function of the four glomerular and tubular function of cell destruction occurred . At this point, people will come to a meaningful conclusion : the decline of renal function Renal Unit is - glomerular filtration and tubular function and return the result of decreased absorption , and renal tubular dysfunction the reason is the functional glomerular and tubular cells - glomerular capillary endothelial cells, mesangial cells, epithelial cells, and tubular epithelial cells in the functional decline is a result of the destruction . Study here, we finally found the real reason for the decline in glomerular filtration rate - the composition of the unit cell renal function , renal function that is inherent in the function of cells was decreased after injury damages .