FSGS will develop into renal failure, please carefully

You know that FSGN is a disease which is caused by the epithelial cells get damaged. The main pathogenetic causes of FSGN are two aspects:
 1). the internal kidney reason like own immunity decrease.

2). the external kidney reasons like antigen of the infection, cold etc. combined with antibody after invade into human body, then form the immune complex of antigen and antibody( mainly featured by IgM and C3 deposition), these immune complex will flow with blood circulation and deposit in the glomerular capillary loops, which gives rise to segmental hyaline degeneration in the epithelial cells of the glomerulus, the surface of epithelial cells of the glomerulus is desquamation, inflammatory mediator continue to invade, thus leading to the function of epithelial cells which have negative electrostatic/charge barrier get damaged, protein in the blood which contains negative charge will run into urine when the barrier function of epithelial cells get damaged, then discharge out of body with urine.At the same time, after epithelial cells get damaged, they will turn into myofibroblast, thus giving rise to glomerulosclerosis, start the process of renal fibrosis. At this time, the urine test shows protein are +.You know without a proper treatment it will develop into renal failure.