Kidney disease in patients with smoking affect rehabilitation

" Nephrotic syndrome " (nephrotic syndrome, NS) referred to renal comprehensive , is referred to by a variety of causes , in order to increase the glomerular basement membrane permeability and decreased glomerular filtration rate associated with glomerular lesions Lord, a group of syndromes . Clinical has four characteristics : ① proteinuria , more than 3.5g / d, the urine may have lipid ; ② hypoalbuminemia , serum albumin less than 30g / L; ③ hyperlipidemia ; ④ edema. Depending on the etiology and pathology of the levy will be divided into three categories : the primary nephrotic syndrome , congenital nephrotic syndrome, secondary nephrotic syndrome.
Most patients with nephrotic syndrome all know smoking on their own rehabilitation disadvantage, but most people are unable to control . Here to remind yourself what the patient can not control cravings , at least not to smoke during the medication. Large number of medical studies have shown that smoking during the medication will affect drug metabolism in nephrotic syndrome , affect the drug's effectiveness , even adversely affected by illness .
Cigarettes contain nicotine in the human body , may cause liver metabolic enzyme systems have an impact, so that the process of drug metabolism to speed up or slow down , resulting in an effective reduction in the concentration of drug in the blood , can not play its due role. Nicotine release of antidiuretic hormone , so that metabolites nephrotic syndrome can not be discharged , leading to accumulation of toxic drugs . Further , excessive loss of smoking synthetic vitamin C, vitamin B6 and vitamin B12 and various essential minerals needed nutrients indirectly adversely affect the course of drug treatment .
Not all drugs are significantly affected by smoking . Medical research shows that drug efficacy has obviously been smoking affects antipyretic analgesics, anesthetics , asthma drugs, anti- angina drugs , antiplatelet agents , lipid-lowering drugs, antidiabetic drugs , patients with nephrotic syndrome, diuretics, anti- antacids , mucosal protective drugs, contraceptives , a common theophylline, caffeine , propranolol, antipyrine , imipramine , phenacetin, a new analgesic , propoxyphene , furosemide .

So remind nephrotic syndrome patients during the medication must be extra careful. Especially for those patients with diabetic nephropathy , and smoking a great impact on morbidity and treatment. Do not smoke in the patients with oral pharmaceutical thirty minutes , once this time will be unable to control the plasma concentration will be reduced so that non-smokers when 1/20 , resulting in efficacy can not function properly .