Hypertension is the cause of microalbuminuria it?

Hypertension is the cause of microalbuminuria it? Hypertensive patients do urine tests can help us understand the extent of kidney damage . A clear relationship between high blood pressure and kidney disease , but the presence of the shortcomings of poor sensitivity of conventional urine detection method. In recent years, some hospitals have launched a number of new more sensitive method for the determination of urinary albumin and N- acetyl -β group glucose glycol (NAG), retinol binding protein (RBP), urinary immunoglobulin G ( IgG) , etc., can be early detection of subclinical microalbuminuria . It is beneficial for a variety of diseases such as diabetes, hypertension and kidney damage or kidney disease early diagnosis and treatment.
( 1 ) microalbuminuria urinary albumin excretion refers to exceed 20 micrograms or 24 hours per minute over 30 mg. Urinary albumin excretion and blood pressure are closely related , at about mild hypertension, microalbuminuria was 5% ; blood pressure was significantly elevated (> 170-180/100mmHg) microalbuminuria in hypertensive patients with the principle of universal and serious. Its mechanism of hypertension increases the pressure within the glomeruli and filtration fraction increased, causing functional and structural abnormalities of the glomerular basement membrane . Therefore , only the blood pressure in hypertensive patients was significantly higher before microalbuminuria appears.
( 2 ) diabetes due to abnormal changes in the glomerular basement membrane charge , glomerular basement membrane thickening system . The increased permeability to albumin , diabetic nephropathy only increased glomerular filtration rate . Only after microalbuminuria , blood pressure can be gradually increased. Compared with diabetic patients with hypertension , the blood pressure is 170-180/100mmHg same level . Diabetes than the average urinary albumin excretion in hypertensive patients 100 times . Therefore , the evaluation of urinary albumin excretion in early diabetic nephropathy is more sensitive and important. When hypertension and diabetes , urinary albumin excretion skyrocketed . The prognosis is poor.

( 3 ) A number of clinical drug studies are used as indicators of albumin excretion were observed protective effect of drugs on the kidney , for example, converting enzyme inhibitor Lotensin treatment of renal failure in patients with a variety of international APRIE trials. In addition to the most common urinary albumin excretion to reflect glomerular lesions unpredictable outside , NAG and RBP is a reflection of renal tubular function indicators. NAG is an enzyme , mainly from the renal proximal tubule epithelial cells , RBP is a binding protein , and its content reflects renal tubular reabsorption , suggesting that high blood pressure or diabetes when they are due to increased tubular reabsorption dysfunction . So far, the urinary excretion of albumin micro- nation is not simply used to detect kidney disease , it has been considered to be an independent predictor of hypertension in patients with small vessel damage , retinal change than a more sensitive indicator .