Forward after renal transplantation due to elevated serum creatinine What are the reasons?

Chronic renal allograft dysfunction is most prelude graft dysfunction, although new immunosuppressive agents and infection control measures applied, making the loss of acute graft decreased significantly, but the loss did not improve long-term kidney transplant, kidney transplant patients currently face The main risk factors for: cardiovascular disease, cancer, infection leads to death and chronic allograft dysfunction leading to graft loss.
Chronic renal allograft dysfunction caused by many factors, common are the following:
1, donor type (live or dead body),
2, hot and cold ischemic time is too long
3, there have been previous acute rejection,
4, advanced chronic rejection
5, primary glomerular disease recurrence,
6, delayed graft function after recovery
7, BK virus-associated nephropathy
8, the transplanted kidney Doppler ultrasound, vascular resistance index (RI)> 0.80
9, diabetes, hypertension,
10 histocompatibility antigen pair does not meet the elevated levels of reactive antibody
11, subclinical rejection,
12, poor patient compliance, treatment does not conform
13 transplant renal artery stenosis
14 renal transplant urinary tract obstruction
15 recipients of lower urinary tract obstruction
16, nephrotoxic immunosuppressive

The above situation can cause chronic renal allograft dysfunction, so the above reasons for the identification of renal transplant protection is very important. Many reasons clearly need a transplant biopsy, so transplant biopsy is very important. Only by examining and even transplant biopsy to confirm the diagnosis and for treatment in order to achieve therapeutic effect, prolonging graft survival time.