3 + proteinuria what disease

Normal urine contained no or only trace amounts of protein, test results were negative (-), when urine protein content up to a certain amount on the positive test result (+). Urine protein 3 + (+ + +, three plus) is doing 24-hour urinary protein excretion results testing, urine protein plus three is meant 1L urine contains protein 2.0-4.0g, ie 2.0-4.0 g / L. Therefore, the Chinese Academy of Military Medical kidney treatment center experts remind our friends, if urine protein has been promoted three plus harm is quite large, specifically:
A biological fluctuations tubule cells: the emergence of many kidney disease with proteinuria are present excessive cell proliferation, represents a non-adaptive response, leading to kidney failure. Tubule proteins directly regulate cell function, growth characteristics and changes in cytokines and phenotypic expression of matrix proteins, the substrate side can cause the release of a small tube PDGF, FN, and MCP-1, induced fibrosis. Click on online consulting experts
Second, the cause tubulointerstitial hypoxia increased: urine protein reabsorption each extra energy to digest large amounts of protein can cause tubule cells of oxygen, resulting in cell damage caused by a small tube.
Third, mesangial Toxicity: renal failure models, can be observed in the serum protein accumulation in mesangial those macromolecules in the aggregate may cause mesangial cell injury mesangial proliferative membrane matrix synthesis each department increased, resulting in glomerular sclerosis. Nephrotic proteinuria model, glomeruli low density lipoprotein (LDL) and very low density lipoprotein (VLDL) apolipoprotein B and apolipoprotein A deposition can also lead those gathered eventually glomerulosclerosis.

Fourth, the urine protein 3 + reasons: mainly by glomerular filtration membrane damage caused by increased permeability caused by glomerular filtration membrane permeability enhancement means that started renal fibrosis, if not promptly treatment, further spread of the disease, renal intrinsic cells will be transformed phenotype occurs easily be generated fibrin degradation of collagen deposition in the kidneys gradually replace healthy kidney units will eventually develop into end-stage renal failure - uremia.