Comprehensive Kidney patients showed proteinuria PRO reasons

In fact, the protein in the body every day to follow certain rules in the body circulation . Follow the blood circulation of the body in which it will pass through the kidneys. What renal comprehensive patient showed proteinuria PRO is the reason? Already have glomerular filtration membrane filtration in the kidneys of the more it will come out . According to the site Invited nephrotic kidney specialists He Ruiqi Director said , when this layer of protective film damage will show such results.
First, the glomerular filtration membrane consists of three parts, namely, from the inside to the outside wall of the capillary endothelial cells, basement membrane and epithelial cells. Blood flow through the kidneys when the small molecules of toxic substances can leach out of the body , such as the protein macromolecules will be asked to stay down.
Second , the principle of the glomerular filtration membrane filtration is actually just the same screen , the size of the drain port is fixed , it is possible to retain more than a molecular diameter smaller than the filtration , which belongs to the physical layer barrier. Further, the upper surface will be covered with a layer of filtration membrane proteins and the negatively charged sialic acid Heparin Sulfate , and protein in the body are usually with a negative charge , so that due to the "negative negative exclusion" principle is also protein will not pass over .
Ultimately, the regulatory function of the membrane filtration system monitors mesangial ball , if the feedback showed doubt seize the time to go out and kidney filtration function will be enhanced over the foot needs .

But according to my site贺瑞岐director of the National Kidney Hospital kidney belongs Survey of explanation, this balance will be due to the condition of renal cell damage and was unbalanced. As part of the barrier to loss of function, leak and substance becomes larger with less negative charge , even if there tubules also totally failed in all of the efficacy of protein reabsorbed back will allow kidney patients showed proteinuria consolidated PRO 's case . The urinalysis and renal function tests can observe changes in proteinuria PRO .