In fact, the protein in the body every day to follow certain rules in the
body circulation . Follow the blood circulation of the body in which it will
pass through the kidneys. What renal comprehensive patient showed proteinuria
PRO is the reason? Already have glomerular filtration membrane filtration in the
kidneys of the more it will come out . According to the site Invited nephrotic
kidney specialists He Ruiqi Director said , when this layer of protective film
damage will show such results.
First, the glomerular filtration membrane consists of three parts, namely,
from the inside to the outside wall of the capillary endothelial cells, basement
membrane and epithelial cells. Blood flow through the kidneys when the small
molecules of toxic substances can leach out of the body , such as the protein
macromolecules will be asked to stay down.
Second , the principle of the glomerular filtration membrane filtration is
actually just the same screen , the size of the drain port is fixed , it is
possible to retain more than a molecular diameter smaller than the filtration ,
which belongs to the physical layer barrier. Further, the upper surface will be
covered with a layer of filtration membrane proteins and the negatively charged
sialic acid Heparin Sulfate , and protein in the body are usually with a
negative charge , so that due to the "negative negative exclusion" principle is
also protein will not pass over .
Ultimately, the regulatory function of the membrane filtration system
monitors mesangial ball , if the feedback showed doubt seize the time to go out
and kidney filtration function will be enhanced over the foot needs .
But according to my site贺瑞岐director of the National Kidney Hospital kidney
belongs Survey of explanation, this balance will be due to the condition of
renal cell damage and was unbalanced. As part of the barrier to loss of
function, leak and substance becomes larger with less negative charge , even if
there tubules also totally failed in all of the efficacy of protein reabsorbed
back will allow kidney patients showed proteinuria consolidated PRO 's case .
The urinalysis and renal function tests can observe changes in proteinuria PRO
.
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