How much do you know about renal fibrosis

Renal fibrosis is a pathophysiological changes , kidney function is to damage the health , to damage , loss of function until a gradual process . Kidney due to a variety of pathogenic factors that stimulate trauma , infection , inflammation, blood circulation disorders , and immune response , its inherent cell damage, to the late development of a large number of collagen deposition and accumulation , resulting in the gradual hardening of renal scarring , until the kidney complete loss of organ function . Intrinsic kidney fibrosis , the hardening process is the process of renal fibrosis . Renal fibrosis is an extracellular matrix (ECM) is characterized by the abnormal deposition .
An inflammatory reaction of
After that period is subject to a variety of causes renal tissue injury, inflammation occurs stage , this is just a phase in addition to the clinical urine abnormalities, without any discomfort , also known as asymptomatic period . Since glomerular filtration compensatory strong at this time can not be affected or mild renal damage after renal pathologic internal damage is a serious inflammation , some patients have glomerular sclerosis, the clinical symptoms appear is lagging behind . If the standard treatment period . Such as the use of vasodilators, anti-inflammatory, anticoagulant , anti- thrombosis and degrading treatment , the disease is completely reversed , even cured. If not standard treatment , or miss the timing of treatment , kidney damage internal pathology will gradually increase, the disease will rapidly to fibrosis and scarring of the period, will bring very difficult to treat , and the more difficult and less opportunity to reverse .
Two of fibrosis
The formation of kidney fibrosis has grown to full kidney tissue , fibrosis inflammatory injury after the ring has been broken health renal units , affecting kidney function , the condition has been entered into or kidney failure decompensation period . If you continue to regulate the treatment period , continue vasodilator , anti-inflammatory , anticoagulant and measures focused on the treatment of fibrous tissue degradation , deprivation therapy as long as these four measures are in place , the disease is likely to be reversed , away from dialysis ; If you did not effective prevention and control of risk factors, not able to control diet or treatment is not in place , if missed some reversible factors favorable timing of treatment, the disease will soon enter the scarring of - end-stage uremia .
Three of scar formation
Once kidney fibrous tissue develop into scar tissue , is never reversed. If patients have more than 1000 ml of urine , it shows there remain residual urine kidney function , multi-target by Micro-Chinese Medicine treatment can protect as long as the current residual renal units , so that no further deterioration of renal function progress on hopefully gradually lengthen the time or gradually get rid of dialysis dialysis .

To facilitate understanding, will simplify the process of renal fibrosis in the second phase , one reversible phase , namely: inflammation of fibrosis formed early, this period in time as standard treatment , its pathological lesions of fibrosis can be cured. Second phase is irreversible , that is scar formation, when once functional nephron become scar tissue is irreversible.