Adult polycystic kidney disease diagnostic methods are there? How to diagnose adult polycystic kidney disease ?

Pros and cons of ( a ) the adult polycystic kidney disease (ADPKD) traditional diagnostic methods.
1 , polycystic kidney disease traditional diagnostic methods:
Combination of family genetic history , to check kidneys, liver, lungs , spleen, ovaries and other parts by B -mode ultrasound , CT and other imaging methods , detection and diagnosis of polycystic kidney disease , polycystic liver is today both convenient and accurate diagnostic tool . Conventional diagnostic techniques currently taken to discover a series of patients with polycystic kidney disease have not been cognitive family .
2 , the traditional diagnostic methods polycystic drawbacks :
However, polycystic kidney disease , polycystic liver patients in the absence of symptoms related to not being taken seriously before the signs , it will not do the check , but not in time to do early diagnosis . In addition to some family members had onset , when the onset of the investigation , as do the families of checks to identify potential patients. Otherwise it can not be diagnosed , and then caused a delay in treatment timing. Moreover, as the B-ultrasound , CT, MRI examination , inspection forms are kidney , kidney organizational structure, cyst size increases when the cyst was discovered after : If B can only be found in more than 1cm super cyst , CT can only find 0.5 cm above the cyst ; MRI found only 0.3cm above the cyst. Kidney morphology and structural changes to be made ​​after the inspection , after all, would delay the early diagnosis of polycystic kidney disease , but also delay the timing of early treatment .
( B) the status of polycystic kidney disease molecular diagnostics and abroad ? ? Early diagnosis of polycystic kidney disease
1985 Reeders methods such as the use of genetic linkage successful diagnosis ADPKD, creating a precedent for molecular diagnosis of polycystic kidney disease . Has been widely applied :
1 , denaturing high-performance liquid chromatography (DHPLC)

Reverse phase chromatography using an ion by the DNA separation matrix , separation of the reaction product specific PCR. Heteroduplex analysis by temperature adjustment , automatic detection of a single set of base substitutions, deletions , and changes in such small fragments inserted gene sequences . With high sensitivity , specificity, saving time, effort and low cost advantages , the detection rate of over 95%.